• APOE and Alzheimer’s disease: from lipid transport to physiopathology and therapeutics.

Husain MA, Laurent B, Plourde M.

Front Neurosci. 2021. In press


  • Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2.

Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH.

Theranostics. 2020 Jan 1;10(1):201-217. PMID: 31903115


  • Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network.

Tsai PH*, Chien Y*, Wang ML*, Hsu CH*, Laurent B*, Chou SJ, Chang WC, Chien CS, Li HY, Lee HC, Huo TI, Hung JH, Chen CH, Chiou SH. (*co-first authors)

Nucleic Acids Res. 2019 Nov 4;47(19):10115-10133. PMID: 31555818


  • AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W.

Nat Cell Biol. 2019 Feb;21(2):226-237. PMID: 30692625


  • Downregulation of ribosome biogenesis during early forebrain development.

Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK.

Elife. 2018 May 10;7. pii: e36998. PMID: 29745900


  • Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.

Chen HY, Lin LT, Wang ML, Laurent B, Hsu CH, Pan CM, Jiang WR, Chen PY, Ma HI, Chen YW, Huang PI, Chiou A, Chiou SH.

Sci Rep. 2017 Aug 18;7(1):8710. PMID: 28821879


  • RNA m6A methylation regulates the ultraviolet-induced DNA damage response.

Xiang Y*, Laurent B*, Hsu CH*, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, Shi Y. (*co-first authors)

Nature. 2017 Mar 23;543(7646):573-576. PMID: 28297716


  • A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.

Iberg-Badeaux A, Collombet S, Laurent B, van Oevelen C, Chin KK, Thieffry D, Graf T, Shi Y.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00372-16. PMID: 27920256


  • Expression, Purification, and Biochemical Analysis of the LSD1/KDM1A Histone Demethylase.

Laurent B, Shi Y.

Methods Enzymol. 2016;573:241-59. PMID: 27372756


  • JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG.

Genes Dev. 2015 Oct 15;29(20):2123-39. PMID: 26494788


  • A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation.

Laurent B, Ruitu L, Murn J, Hempel K, Ferrao R, Xiang Y, Liu S, Garcia BA, Wu H, Wu F, Steen H, Shi Y.

Mol Cell. 2015 Mar 19;57(6):957-970. PMID: 25684206


  • Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.

Brookes E, Laurent B, Õunap K, Carroll R, Moeschler JB, Field M, Schwartz CE, Gecz J, Shi Y.

Hum Mol Genet. 2015 May 15;24(10):2861-72. PMID: 25666439


  • The histone demethylase LSD1/KDM1A promotes the DNA damage response.

Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y.

J Cell Biol. 2013 Nov 11;203(3):457-70. PMID: 24217620


  • A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.

Laurent B, Randrianarison-Huetz V, Frisan E, Andrieu-Soler C, Soler E, Fontenay M, Dusanter-Fourt I, Duménil D.

J Cell Sci. 2012 Feb 15;125(Pt 4):993-1002. PMID: 22399799


  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.

Randrianarison-Huetz V*, Laurent B*, Bardet V, Blobe GC, Huetz F, Duménil D. (*co-first authors)

Blood. 2010 Apr 8;115(14):2784-95. PMID: 20124515


  • High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription.

Laurent B, Randrianarison-Huetz V, Maréchal V, Mayeux P, Dusanter-Fourt I, Duménil D.

Blood. 2010 Jan 21;115(3):687-95. PMID: 19965638


  • Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells.

Laurent B, Randrianarison-Huetz V, Kadri Z, Roméo PH, Porteu F, Duménil D.

Stem Cells. 2009 Sep;27(9):2153-62. PMID: 19522008


  • The family of Gfi-1 zinc finger transcriptional repressor oncoproteins in hematopoiesis regulation.

Laurent B, Randrianarison V, Duménil D.

Hématologie. 2006 Nov-Dec; 12(6):379-388. [link]