Aging is the outcome of complex changes in our biological functions that are responsible for the increased risk of disease and death. The overarching goal of our lab is to decipher the etiology of brain aging. We aim to provide important insights into the age-related changes occurring at the level of our (epi)genomes, cells and tissues, and to identify new strategies for slowing cognitive decline and reducing the incidence of neurodegenerative diseases during aging. Our attention is primarily focused on the study of two molecular mechanisms that maintain the structure and functions of the brain: alternative RNA splicing and chromatin structure regulation. We are investigating how these two mechanisms interplay to orchestrate the brain development and maintain the brain homeostasis. We are interested in comprehending how deregulations of these events are responsible of the physiological and anatomical changes observed during brain aging and in neurodegenerative diseases.