Publications

  • Coordinated neuron-specific splicing events restrict nucleosome engagement of the LSD1 histone demethylase complex.

Porter RS, An S, Gavilan MC, Nagai M, Murata-Nakamura Y, Zhou B, Bonefas KM, Dionne O, Manuel JM, St-Germain J, Gascon S, Kim J, Browning L, Laurent B, Cho US, Iwase S.

Cell Reports. 2025; in press. PMID: 37904995

 

  • Deciphering the physiopathology of neurodevelopmental disorders using brain organoids.

Dionne O, Sabatié S, Laurent B.

Brain. 2025; in press. PMID: 39222411

 

  • Efficient generation of human induced pluripotent stem cells from urine samples of patients with Fragile X syndrome.

Dionne O, Sabatié S, Fortin F, Corbin F, Laurent B.

Front Cell Dev Biol. 2024 Nov 22;12:1489190. PMID: 39650724

 

  • Providing lysophosphatidylcholine-bound omega-3 fatty acids increased eicosapentaenoic acid, but not docosahexaenoic acid, in the cortex of mice with the apolipoprotein E3 or E4 allele.

Andriambelo B, Vachon A, Dansereau MA, Laurent B, Plourde M.

Prostaglandins Leukot Essent Fatty Acids. 2024 Nov 30:204:102661. PMID: 39642444

 

  • Assessing tissue mechanical properties: Development of a custom-made tensile device and application on rodents sciatic nerves.

Petit E, Bavykina V, Thibault M, Bilodeau A, Choinière W, Brosseau JP, Laurent B, Lauzon MA.

J Mech Behav Biomed Mater. 2024 Nov;159:106709. PMID: 39216337

 

  • In Vitro Assessment of the Neuroprotective Effects of Pomegranate (Punica granatum L.) Polyphenols Against Tau Phosphorylation, Neuroinflammation, and Oxidative Stress.

Alami M, Boumezough K, Zerif E, Zoubdane N, Khalil A, Bunt T, Laurent B, Witkowski JM, Ramassamy C, Boulbaroud S, Fulop T, Berrougui H.

Nutrients. 2024 Oct 28;16(21):3667. PMID: 39519499

 

  • Viruses - a major cause of amyloid deposition in the brain.

Fulop T, Ramassamy C, Lévesque S, Frost EH, Laurent B, Lacombe G, Khalil A, Larbi A, Hirokawa K, Desroches M, Rodrigues S, Bourgade K, Cohen AA, Witkowski JM.

Expert Rev Neurother. 2023 Jul-Dec;23(9):775-790. PMID: 37551672

 

  • Distinct regulatory functions and biological roles of lncRNA splice variants.

Khan MR, Avino M, Wellinger RJ, Laurent B.

Mol Ther Nucleic Acids. 2023 Mar 15;32:127-143. PMID: 37025931

 

  • Re-evaluating the impact of alternative RNA splicing on proteomic diversity.

Manuel JM, Guilloy N, Khatir I, Roucou X, Laurent B.

Front Genet. 2023 Feb 9;14:1089053. PMID: 36845399

 

  • Decoupling of mRNA and protein expression in aging brains reveals the age-dependent adaptation of specific gene subsets.

Khatir I, Brunet MA, Meller A, Amiot F, Patel T, Lapointe X, Avila Lopez J, Guilloy N, Castonguay A, Husain MA, St Germain J, Boisvert FM, Plourde M, Roucou X, Laurent B.

Cells. 2023 Feb 14;12(4):615. PMID: 36831282

 

  • Functional characterization of a Phf8 processed pseudogene in the mouse genome.

St-Germain J, Khan MR, Bavykina V, Desmarais R, Scott M, Boissonneault G, Brunet MA, Laurent B.

Genes. 2023 Jan 8;14(1):172. PMID: 36672913

 

  • Interaction mechanism between the HSV-1 glycoprotein B and the antimicrobial peptide amyloid-β.

Bourgade K, Frost EH, Dupuis G, Witkowski JM, Laurent B, Calmettes C, Ramassamy C, Desroches M, Rodrigues S, Fülöp T Jr.

J Alzheimers Dis Rep. 2022 Sep 24;6(1):599-606. PMID: 36275414

 

  • Transcriptomic modulation in response to high-intensity interval training in monocytes of older women with type 2 diabetes.

Hamelin Morrissette J, Tremblay D, Marcotte-Chénard A, Lizotte F, Brunet MA, Laurent B, Riesco E, Geraldes P.

Eur J Appl Physiol. 2022 Apr;122(4):1085-1095. PMID: 35182182

 

  • Immunosenescence and Alzheimer’s Disease.

Fulop T, Larbi A, Khalil A, Plotka A, Laurent B, Ramassamy C, Bosco N, Hirokawa K, Frost EH, Witkowski JM.

Chapter in Healthy Longevity and Immune System. 2022 Jan;p:177–199. SpringerLink

 

  • Exploring the alternative splicing of long noncoding RNAs.

Khan MR, Wellinger RJ, Laurent B.

Trends Genet. 2021 Aug;37(8):695-698. PMID: 33892960

 

  • Hyperactivation of monocytes and macrophages in MCI patients contributes to the progression of Alzheimer's disease.

Munawara U, Catanzaro M, Xu W, Tan C, Hirokawa K, Bosco N, Dumoulin D, Khalil A, Larbi A, Lévesque S, Ramassamy C, Barron AE, Cunnane S, Beauregard PB, Bellenger JP, Rodrigues S, Desroches M, Witkowski JM, Laurent B, Frost EH, Fulop T.

Immun Ageing. 2021 Jun 21;18(1):29. PMID: 34154615

 

  • MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus.

Kaiser K, Jang A, Kompanikova P, Lun MP, Prochazka J, Machon O, Dani N, Prochazkova M, Laurent B, Gyllborg D, van Amerongen R, Fame RM, Gupta S, Wu F, Barker RA, Bukova I, Sedlacek R, Kozmik Z, Arenas E, Lehtinen MK, Bryja V.

Development. 2021 May 15;148(10):dev192054. PMID: 34032267

 

  • Targeting impaired antimicrobial immunity in the brain for the treatment of Alzheimer's disease.

Fulop T, Tripathi S, Rodrigues S, Desroches M, Bunt T, Eiser A, Bernier F, Beauregard PB, Barron AE, Khalil A, Plotka A, Hirokawa K, Larbi A, Bocti C, Laurent B, Frost EH, Witkowski JM.

Neuropsychiatr Dis Treat. 2021 May 4;17:1311-1339. PMID: 33976546

 

  • Lipid transport and metabolism at the blood-brain interface: implications in health and disease.

Pifferi F, Laurent B, Plourde M.

Front Physiol. 2021 Mar 30;12:645646. PMID: 33868013

 

  • APOE and Alzheimer’s disease: from lipid transport to physiopathology and therapeutics.

Husain MA, Laurent B, Plourde M.

Front Neurosci. 2021 Feb 17;15:630502. PMID: 33679311

 

  • Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2.

Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH.

Theranostics. 2020 Jan 1;10(1):201-217. PMID: 31903115

 

  • Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network.

Tsai PH*, Chien Y*, Wang ML*, Hsu CH*, Laurent B*, Chou SJ, Chang WC, Chien CS, Li HY, Lee HC, Huo TI, Hung JH, Chen CH, Chiou SH. (*co-first authors)

Nucleic Acids Res. 2019 Nov 4;47(19):10115-10133. PMID: 31555818

 

  • AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions.

Guo J, Dai X, Laurent B, Zheng N, Gan W, Zhang J, Guo A, Yuan M, Liu P, Asara JM, Toker A, Shi Y, Pandolfi PP, Wei W.

Nat Cell Biol. 2019 Feb;21(2):226-237. PMID: 30692625

 

  • Downregulation of ribosome biogenesis during early forebrain development.

Chau KF, Shannon ML, Fame RM, Fonseca E, Mullan H, Johnson MB, Sendamarai AK, Springel MW, Laurent B, Lehtinen MK.

Elife. 2018 May 10;7. pii: e36998. PMID: 29745900

 

  • Musashi-1 Enhances Glioblastoma Cell Migration and Cytoskeletal Dynamics through Translational Inhibition of Tensin3.

Chen HY, Lin LT, Wang ML, Laurent B, Hsu CH, Pan CM, Jiang WR, Chen PY, Ma HI, Chen YW, Huang PI, Chiou A, Chiou SH.

Sci Rep. 2017 Aug 18;7(1):8710. PMID: 28821879

 

  •  RNA m6A methylation regulates the ultraviolet-induced DNA damage response.

Xiang Y*, Laurent B*, Hsu CH*, Nachtergaele S, Lu Z, Sheng W, Xu C, Chen H, Ouyang J, Wang S, Ling D, Hsu PH, Zou L, Jambhekar A, He C, Shi Y. (*co-first authors)

Nature. 2017 Mar 23;543(7646):573-576. PMID: 28297716

 

  •  A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.

Iberg-Badeaux A, Collombet S, Laurent B, van Oevelen C, Chin KK, Thieffry D, Graf T, Shi Y.

Mol Cell Biol. 2017 Feb 1;37(4). pii: e00372-16. PMID: 27920256
 

  • Expression, Purification, and Biochemical Analysis of the LSD1/KDM1A Histone Demethylase.

Laurent B, Shi Y.

Methods Enzymol. 2016;573:241-59. PMID: 27372756

 

  • JMJD1C is required for the survival of acute myeloid leukemia by functioning as a coactivator for key transcription factors.

Chen M, Zhu N, Liu X, Laurent B, Tang Z, Eng R, Shi Y, Armstrong SA, Roeder RG.

Genes Dev. 2015 Oct 15;29(20):2123-39. PMID: 26494788

 

  • A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation.

Laurent B, Ruitu L, Murn J, Hempel K, Ferrao R, Xiang Y, Liu S, Garcia BA, Wu H, Wu F, Steen H, Shi Y.

Mol Cell. 2015 Mar 19;57(6):957-970. PMID: 25684206

 

  • Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity.

Brookes E, Laurent B, Õunap K, Carroll R, Moeschler JB, Field M, Schwartz CE, Gecz J, Shi Y.

Hum Mol Genet. 2015 May 15;24(10):2861-72. PMID: 25666439

 

  • The histone demethylase LSD1/KDM1A promotes the DNA damage response.

Mosammaparast N, Kim H, Laurent B, Zhao Y, Lim HJ, Majid MC, Dango S, Luo Y, Hempel K, Sowa ME, Gygi SP, Steen H, Harper JW, Yankner B, Shi Y.

J Cell Biol. 2013 Nov 11;203(3):457-70. PMID: 24217620

 

  • A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.

Laurent B, Randrianarison-Huetz V, Frisan E, Andrieu-Soler C, Soler E, Fontenay M, Dusanter-Fourt I, Duménil D.

J Cell Sci. 2012 Feb 15;125(Pt 4):993-1002. PMID: 22399799

 

  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.

Randrianarison-Huetz V*, Laurent B*, Bardet V, Blobe GC, Huetz F, Duménil D. (*co-first authors)

Blood. 2010 Apr 8;115(14):2784-95. PMID: 20124515

 

  • High-mobility group protein HMGB2 regulates human erythroid differentiation through trans-activation of GFI1B transcription.

Laurent B, Randrianarison-Huetz V, Maréchal V, Mayeux P, Dusanter-Fourt I, Duménil D.

Blood. 2010 Jan 21;115(3):687-95. PMID: 19965638

 

  • Gfi-1B promoter remains associated with active chromatin marks throughout erythroid differentiation of human primary progenitor cells.

Laurent B, Randrianarison-Huetz V, Kadri Z, Roméo PH, Porteu F, Duménil D.

Stem Cells. 2009 Sep;27(9):2153-62. PMID: 19522008

 

  • The family of Gfi-1 zinc finger transcriptional repressor oncoproteins in hematopoiesis regulation.

Laurent B, Randrianarison V, Duménil D.

Hématologie. 2006 Nov-Dec; 12(6):379-388. [link]